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[Modified circulating low-density lipoproteins: pathogenetic significance in angiology]
Ya D Babintseva1, V P Karagodin2, A N Orekhov3
1Scientific Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
|December 10, 2016
Summary
Circulating modified low-density lipoproteins (cmLDLs) are linked to atherosclerosis. These modified LDLs exhibit distinct biochemical and physical properties, contributing to vascular wall changes and disease progression.
Area of Science:
- Cardiovascular Research
- Biochemistry
- Pathology
Background:
- Modified low-density lipoproteins (LDLs) are implicated in atherogenesis.
- Circulating modified LDLs (cmLDLs) are present in patients with angiographically confirmed atherosclerosis.
- cmLDLs exhibit altered biochemical and physical properties compared to native LDLs.
Purpose of the Study:
- To review multi-year studies on the effects of cmLDLs on the vascular wall.
- To elucidate the role of modified LDLs in the pathogenesis of atherosclerosis.
Main Methods:
- Comparative analysis of LDL properties in patients with atherosclerosis versus healthy individuals.
- Characterization of physical and chemical differences in cmLDLs.
- Investigation of cmLDL-induced smooth muscle cell proliferation and matrix synthesis.
Main Results:
- cmLDLs have lower sialic acid content (2-3 fold) and reduced neutral sugars (1.5-2 fold).
- cmLDLs show higher levels of cholesterol, triglycerides, and free fatty acids.
- cmLDLs are oxidized, contain altered apolipoprotein B, and promote subendothelial smooth muscle cell proliferation.
Conclusions:
- Modified LDLs possess atherogenic properties, inducing atherosclerosis.
- Distinct characteristics of cmLDLs contribute to vascular intima changes and early atherosclerosis manifestations.
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