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[Urticaria and Quincke's edema].
Therapeutische Umschau. Revue Therapeutique
|September 1, 1989
Summary
Urticaria is a common skin condition causing itchy hives due to mast cell activation. Chronic urticaria often has unknown causes, particularly in children, requiring differential diagnosis for effective treatment.
Area of Science:
- Dermatology
- Immunology
- Allergy
Context:
- Urticaria, a prevalent skin condition, manifests as transient, itchy, red, and swollen wheals, occasionally presenting as angioedema.
- Pathogenesis involves mast cell activation via diverse mechanisms, leading to the release of bioactive mediators.
- Chronic urticaria etiology is frequently unidentified (75-80% of cases) and is uncommon in pediatric populations.
Purpose:
- To summarize the characteristics and pathogenesis of urticaria.
- To highlight the diagnostic challenges in chronic urticaria, especially in children.
- To briefly review therapeutic options for urticaria management.
Summary:
- Urticaria involves mast cell degranulation, releasing histamine and other mediators, causing characteristic skin lesions.
- Acute urticaria in children frequently co-occurs with atopic conditions like dermatitis or pollinosis.
- Differential diagnosis is crucial, excluding papular urticaria, urticaria pigmentosa, and hereditary angioedema.
Impact:
- Provides a concise overview of urticaria for healthcare professionals and researchers.
- Emphasizes the importance of distinguishing urticaria subtypes and considering atopic links in children.
- Informs clinical practice regarding the diagnostic and therapeutic considerations for urticaria.