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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
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Long noncoding RNAs: pivotal regulators in acute myeloid leukemia
1State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025 China.
Experimental Hematology & Oncology
|December 22, 2016
Summary
Long noncoding RNAs (lncRNAs) are key gene regulators in acute myeloid leukemia (AML). This review covers their roles in AML development, function, and as potential prognostic markers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are increasingly recognized as crucial regulators of gene expression.
- Recent research implicates lncRNAs in the initiation, progression, and development of acute myeloid leukemia (AML).
Approach:
- This review synthesizes current knowledge on lncRNAs involved in AML pathogenesis.
- It details lncRNA characteristics and their regulatory functions in crucial cellular processes like differentiation, proliferation, cell cycle, and apoptosis.
- Mechanisms of lncRNA action, including interactions with RNA, proteins, and DNA, are explored.
Key Points:
- lncRNAs significantly influence key biological processes in AML, including cell differentiation, proliferation, cell cycle control, and apoptosis.
- lncRNAs exert their functions through diverse molecular interactions, affecting RNA, protein, and chromatin DNA.
- Understanding these mechanisms is vital for deciphering lncRNA contributions to AML pathogenesis.
Conclusions:
- lncRNAs play multifaceted roles in acute myeloid leukemia, impacting its initiation and progression.
- Further investigation into lncRNA mechanisms is essential for understanding AML pathogenesis.
- lncRNAs show promise as potential prognostic biomarkers for AML patients.
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