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Related Concept Videos

Pancreas01:19

Pancreas

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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

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Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
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Erratum.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2020 Annual Data Report: Living Donor Collective

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2020 Annual Data Report: Introduction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
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OPTN/SRTR 2020 Annual Data Report: VCA.

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Technical Detail for Robot Assisted Pancreaticoduodenectomy
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OPTN/SRTR 2015 Annual Data Report: Pancreas.

R Kandaswamy1,2, P G Stock3, S K Gustafson1

  • 1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|January 5, 2017
PubMed
Summary

Pancreas transplant numbers stabilized in the US after a decline. New allocation systems show no immediate impact on transplant types, but graft failure data is pending.

Keywords:
Pancreas transplantpancreas after kidney transplantpancreas transplant alonesimultaneous pancreas-kidney transplant

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Organ Transplantation

Background:

  • Pancreas transplantation in the US experienced a decade-long decline.
  • Recent years have seen a stabilization in pancreas transplant numbers and waiting list additions.
  • The decline in pancreas-after-kidney transplants also appears to have halted.

Purpose of the Study:

  • To analyze trends in pancreas transplantation following the implementation of a new allocation system.
  • To assess the impact of the new allocation system on organ distribution between simultaneous pancreas-kidney (SPK) and pancreas transplant alone (PTA).
  • To highlight ongoing initiatives aimed at improving pancreas organ utilization.

Main Methods:

  • Analysis of pancreas transplant data from the United States.
  • Evaluation of organ distribution patterns before and after the new pancreas allocation system.
  • Review of initiatives by the OPTN/UNOS Pancreas Transplantation Committee.

Main Results:

  • Pancreas transplant numbers and waiting list additions stabilized in the last three years.
  • The new pancreas allocation system did not alter the distribution of organs between SPK and PTA transplants in its first year.
  • The proportion of kidneys used in SPK transplants remained unchanged.
  • A uniform definition for pancreas graft failure was approved but is not yet implemented, impacting outcome trend analysis.

Conclusions:

  • Pancreas transplant activity has stabilized, suggesting a potential shift after a prolonged decline.
  • The current pancreas allocation system has not yet demonstrated a significant change in organ distribution patterns.
  • Future efforts focus on facilitated allocation and ABO-incompatible transplants to enhance organ utilization, while standardized graft failure definitions are awaited to better track outcomes.