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Gliosarcoma with Primary Skull Base Invasion.

Quoc-Bao D Nguyen1, Avital Perry2, Christopher S Graffeo2

  • 1Texas A&M Health Science Center College of Medicine, Temple, TX, USA.

Case Reports in Radiology
|January 6, 2017
PubMed
Summary
This summary is machine-generated.

This case report details a rare gliosarcoma with extensive skull base invasion. The aggressive tumor highlights a previously undocumented pattern of invasion in this rare glioblastoma variant.

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Area of Science:

  • Neuro-oncology
  • Surgical Pathology
  • Neurosurgery

Background:

  • Gliosarcoma, an uncommon glioblastoma variant, typically shows dural attachment but rarely invades the skull base.
  • Skull base invasion by gliosarcoma is exceptionally rare, with limited documented cases.

Purpose of the Study:

  • To report a unique case of primary intracranial gliosarcoma with extensive skull base and extracranial invasion.
  • To highlight the aggressive nature and previously undescribed invasion patterns of gliosarcoma.

Main Methods:

  • Case presentation of a 44-year-old female with a large intracranial gliosarcoma.
  • Diagnostic imaging including Head CT and Brain MRI to characterize tumor extent.
  • Surgical resection via right frontotemporal craniotomy and histopathological confirmation (IDH-wildtype, WHO grade IV).

Main Results:

  • The patient presented with symptoms of jaw dysfunction and retro-orbital pressure, indicative of extensive tumor growth.
  • Imaging revealed a large mass with significant bony erosion, invading the skull base, orbit, and mastication muscles.
  • Gross total resection was achieved, with pathology confirming gliosarcoma, IDH-wildtype (WHO grade IV).

Conclusions:

  • This is the third reported case of primary intracranial gliosarcoma invading the skull base and extracranial compartments.
  • This case represents the first documented instance of gliosarcoma invading surrounding musculature and the orbit.
  • The findings underscore the potential for rapid aggressiveness and diverse invasive patterns in gliosarcoma.