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Multifiber angular compounding optical coherence tomography for speckle reduction.

Dongyao Cui, En Bo, Yuemei Luo

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    This study introduces a novel fiber optic design for multifiber angular compounding optical coherence tomography (OCT). This technique reduces speckle noise, enhancing image quality for biomedical applications.

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    Area of Science:

    • Biomedical Optics
    • Optical Coherence Tomography
    • Fiber Optic Sensing

    Background:

    • Speckle noise in OCT imaging degrades image quality and reduces diagnostic accuracy.
    • Traditional OCT methods often struggle with effective speckle reduction.
    • Angular compounding is a promising technique for mitigating speckle artifacts.

    Purpose of the Study:

    • To develop and validate an integrated fiber optic design for multifiber angular compounding OCT.
    • To demonstrate speckle reduction capabilities of the proposed OCT system.
    • To evaluate the performance of the system in ex vivo biological samples.

    Main Methods:

    • An integrated fiber optic design utilizing a multi-facet fiber array to deliver three beams at different incident angles.
    • Simultaneous detection of back-reflective/back-scattered signals using a three-channel spectrometer.
    • Characterization of axial and lateral resolution, sensitivity, and contrast-to-noise ratio.

    Main Results:

    • Achieved axial and lateral resolutions of approximately 3 μm and 3.5 μm, respectively.
    • Demonstrated high sensitivity of approximately 100 dB.
    • Ex vivo experiments on rat esophagus showed a contrast-to-noise improvement of 1.58.

    Conclusions:

    • The developed multifiber angular compounding OCT system effectively reduces speckle noise.
    • The system offers high resolution and sensitivity suitable for detailed biological imaging.
    • This technology holds potential for improved diagnostic capabilities in various biomedical fields.