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Published on: July 3, 2013
Low-protein diet for the prevention of renal failure
1Life Science Promoting Association.
Insights
A low-protein diet, particularly using specialized low-protein rice, can effectively manage chronic kidney disease (CKD) progression. This dietary intervention helps reduce protein, potassium, and phosphate intake, benefiting patients with declining kidney function.
Area of Science:
- Nephrology
- Dietary Science
- Public Health
Background:
- Chronic kidney disease (CKD) affects 8-16% globally, with increasing prevalence.
- CKD is a significant risk factor for cardiovascular events and kidney failure.
- Diabetic nephropathy is the leading cause of CKD, posing a substantial health burden.
Purpose of the Study:
- To highlight the efficacy of low-protein diets in managing CKD.
- To introduce low-protein rice as a practical dietary intervention.
- To emphasize the importance of protein restriction for slowing CKD progression.
Main Methods:
- Reviewing the impact of dietary protein on CKD.
- Analyzing the benefits of low-protein rice in controlling nutrient intake (protein, potassium, phosphate).
- Defining the threshold for protein restriction based on estimated glomerular filtration rate (eGFR).
Main Results:
- Low-protein diets (less than 0.5 g/kg b.wt.) are highly effective in managing CKD.
- Low-protein rice facilitates controlled protein consumption while reducing potassium and phosphate intake.
- Protein restriction is recommended when eGFR falls below 60 ml/min/1.73 m² to slow disease progression.
Conclusions:
- Dietary protein restriction is a crucial strategy for slowing CKD progression.
- Novel low-protein rice varieties offer a practical solution for patients needing dietary management.
- This approach holds promise for improving CKD patient outcomes in Asia and globally.
Abstract:
The prevalence of chronic kidney disease (CKD) is estimated to be 8-16% worldwide, and it is increasing. CKD is a risk factor for heart attack and stroke, and it can progress to kidney failure requiring dialysis or transplantation. Recently, diabetic nephropathy has become the most common cause of CKD. In Japan, the cumulative probability of requiring hemodialysis by the age 80 years is 1/50 in males and 1/100 in females. The number of patients under hemodialysis in Japan exceeded 320,000 in 2014, among which 38,000 were newcomers and 27,000 died.The annual medical costs of hemodialysis are 1.25 trillion yen in Japan, representing 4% of the total national medical expenditures in 2014. A low-protein diet (less than 0.5 g/kg b.wt.) is a very effective intervention. Low-protein rice (1/10 to 1/25 of the normal protein contents) is helpful to control the consumption of proteins, decreasing at the same time the intake of potassium and phosphate.Protein restriction is indicated as soon as the eGFR becomes lower than 60 ml/min/1.73 m2 body surface, in order, to slow disease progression. The newly developed low-protein Indica rice is expected to help many CKD patients in China and Southeast Asia.
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