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Identification of a novel HLA-B*40 allele, HLA-B*40:332, in a Korean individual

S-H Han1,2, O-J Kwon3, H-S Lim1

  • 1Division of Molecular Genetics, Department of Laboratory Medicine, Seoul Clinical Laboratories, Yongin, Korea.

HLA
|January 20, 2017
PubMed

Abstract:

HLA-B*40:332 differs from B*40:01:02 by 1 nucleotide difference at nucleotide position 439.

Keywords:
HLA-B*40:332novel allelesequence-based typing

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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