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3D bioprinting and its in vivo applications
Nhayoung Hong1, Gi-Hoon Yang1, JaeHwan Lee2
1Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, South Korea.
Summary
3D bioprinting fabricates functional tissues using bioinks for research and medical applications. While promising, challenges like vascularization require further innovation for successful in vivo organ creation.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- 3D bioprinting, also known as additive biomanufacturing, utilizes bioinks (biomaterials and cells) to create 3D cell-laden structures.
- Applications include research models, drug discovery, toxicology, and in vivo tissue/organ fabrication.
Purpose of the Study:
- To review common 3D cell-printing techniques, detailing their advantages and disadvantages.
- To present current achievements in 3D bioprinting for in vivo applications.
- To discuss future prospects of 3D cell-printing technology.
Main Methods:
- Review of existing literature on 3D bioprinting techniques.
- Analysis of advantages and drawbacks of various methods.
- Compilation of recent advancements and applications in in vivo bioprinting.
Main Results:
- 3D cell-printing enables high-resolution fabrication of cell-laden structures.
- Established applications in research models, drug delivery, and toxicology.
- Significant progress in fabricating tissues and organs, though vascularization remains a challenge.
Conclusions:
- 3D bioprinting offers versatile applications in tissue engineering and regenerative medicine.
- Overcoming challenges like vascularization is crucial for in vivo organ development.
- Continued advancements promise broader clinical applications for 3D bioprinting.
