Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparative Performance of Artificial Intelligence Optical Diagnosis Systems for Leaving in Situ Colorectal Polyps.

Gastroenterology·2022

Same author

Comparison between Enteroscopy-, Laparoscopy- and Endoscopic Ultrasound-Assisted Endoscopic Retrograde Cholangio-Pancreatography in Patients with Surgically Altered Anatomy: A Systematic Review and Meta-Analysis.

Life (Basel, Switzerland)·2022

Same author

Development and validation of artificial neural networks model for detection of Barrett's neoplasia: a multicenter pragmatic nonrandomized trial (with video).

Gastrointestinal endoscopy·2022

Same author

Expected value of artificial intelligence in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

Endoscopy·2022

Same author

Variability in adenoma detection rate in control groups of randomized colonoscopy trials: a systematic review and meta-analysis.

Gastrointestinal endoscopy·2022

Same author

Clinical value of alarm features for colorectal cancer: a meta-analysis.

Endoscopy·2022

Search research articles

Related Experiment Video

Updated: Mar 8, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

Published on: October 19, 2018

Standard needle versus needleless injection modality: animal study on different fluids for submucosal elevation.

Alessandro Repici¹, Roberta Maselli¹, Silvia Carrara¹

¹Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Humanitas University, Milan, Italy.

Gastrointestinal Endoscopy

|February 6, 2017

Summary

Needleless and needle-assisted submucosal injections show similar tissue elevation efficacy in GI endoscopy. More viscous solutions, however, provide higher and more persistent elevations compared to normal saline.

More Related Videos

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

Published on: August 23, 2022

Related Experiment Videos

Last Updated: Mar 8, 2026

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance

Published on: October 19, 2018

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

Published on: August 23, 2022

Area of Science:

Gastroenterology
Endoscopic Procedures
Surgical Innovation

Background:

Submucosal injection is crucial in gastrointestinal (GI) endoscopy for reducing resection risks and enabling submucosal dissection.
Current methods typically involve needle-assisted or needleless injection devices.

Purpose of the Study:

To compare the efficacy of needle-assisted versus needleless submucosal injection techniques.
To evaluate the impact of substance viscosity on submucosal tissue elevation.

Main Methods:

An ex vivo porcine model was used to compare needle and needleless injection techniques.
Five different substances with varying viscosities were injected.
Submucosal elevation height was measured at three time points (t0, t1, t2), and solution viscosity was recorded.

Main Results:

No significant difference in submucosal elevation height or persistence was observed between needleless and needle-assisted techniques in the stomach or rectum (except for initial rectal elevation).
More viscous solutions consistently resulted in significantly higher and more persistent tissue elevations compared to normal saline, irrespective of the injection method.
The initial elevation in the rectum was slightly higher with the needle-assisted technique but not clinically significant.

Conclusions:

Needleless and needle-assisted submucosal injection techniques demonstrate comparable efficacy in achieving and maintaining tissue elevation.
Substance viscosity is a key factor influencing the height and duration of submucosal elevations.
The findings suggest that needleless devices are a viable alternative to needle-assisted methods for submucosal injections.