Computationally Aided Absolute Stereochemical Determination of Enantioenriched Amines
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Updated: Mar 7, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Jun Zhang1, Hadi Gholami1, Xinliang Ding1
1Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United States.
Abstract:
A simple and efficient protocol for sensing the absolute stereochemistry and enantiomeric excess of chiral monoamines is reported. Preparation of the sample requires a single-step reaction of the 1,1'-(bromomethylene)dinaphthalene (BDN) with the chiral amine. Analysis of the exciton coupled circular dichroism generated from the BDN-derivatized chiral amine sample, along with comparison to conformational analysis performed computationally, yields the absolute stereochemistry of the parent chiral monoamine.
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