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Updated: Mar 6, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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SORPTION CORRECTION OF NEPHRON SUB-MICROSCOPIC CHANGES CAUSED BY NEOPLASTIC CHRONIC INTOXICATION WITH THE APPLICATION

Yu Soroka1, N Lisnychuk1, I Demkiv1

  • 1Ternopil State Medical University, Department of Anaesthesiology and Intensive-Care Medicine; Central Scientific Research Laboratory; Ternopil State Medical University, Pharmacology and Clinical Pharmacology Department, Ukraine.

Georgian Medical News
|March 3, 2017
PubMed

Insights

Dimethylhydrazine-induced colorectal cancer causes kidney damage. A novel carbon enterosorbent, Carboline, mitigates these effects, promoting kidney repair and function recovery during chemotherapy.

Area of Science:

  • Nephrology
  • Oncology
  • Toxicology

Background:

  • Dimethylhydrazine (DMH) induces colorectal adenocarcinoma.
  • Carcinogenesis leads to nephron structural damage and impaired urine formation.
  • Chemotherapy can exacerbate kidney injury.

Purpose of the Study:

  • To evaluate electron microscopic changes in nephrons during DMH-induced carcinogenesis.
  • To assess the protective effects of a novel carbon enterosorbent (Carboline) on kidney structure during chemotherapy.

Main Methods:

  • Electron microscopy was used to examine nephron structural components.
  • DMH was administered to induce carcinogenesis.
  • Carboline was applied for chronic neoplastic endotoxemia correction alongside chemotherapy.

Main Results:

  • DMH-induced carcinogenesis caused destructive changes in kidney tubules and renal corpuscles.
  • Cytostatics aggravated kidney damage.
  • Carboline significantly reduced structural damage and activated reparative regeneration in the kidneys.

Conclusions:

  • DMH-induced colorectal cancer negatively impacts kidney morphology and function.
  • Carboline shows potential in mitigating chemotherapy-induced kidney damage and promoting recovery.
  • Restoration of nephron structure indicates functional recovery of the kidneys.

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