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Updated: Mar 6, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Roles of RUNX in Hippo Pathway Signaling

Antonino Passaniti1, Jessica L Brusgard2, Yiting Qiao3

  • 1Department of Pathology and Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, and the Veterans Administration Health Service, Baltimore, MD, USA. TPassaniti@som.umaryland.edu.

Advances in Experimental Medicine and Biology
|March 17, 2017
PubMed

Insights

Runt-domain (RD) transcription factors like RUNX2 and RUNX3 interact with Hippo pathway proteins YAP and TAZ. These interactions play dual roles in cancer, promoting or suppressing tumor growth depending on the specific RUNX gene and cancer type.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Signaling

Background:

  • Runt-domain (RD) transcription factors (RUNX genes) are crucial mediators interacting with Hippo pathway proteins YAP and TAZ.
  • Dysregulation of the Hippo pathway and RUNX factors is implicated in human cancers.
  • Understanding these interactions is key to developing targeted cancer therapies.

Purpose of the Study:

  • To explore the significance of RUNX-TAZ/YAP interactions in human cancer.
  • To highlight contrasting roles of RUNX family members in cancer progression.
  • To identify novel therapeutic strategies targeting Hippo pathway crosstalk in cancer.

Main Methods:

  • Review of recent scientific literature on RUNX-TAZ/YAP interactions.
  • Analysis of specific examples of RUNX2 and RUNX3 involvement in cancer.
  • Focus on epithelial to mesenchymal transition and tumor suppression mechanisms.

Main Results:

  • RUNX2 cooperates with TAZ to promote epithelial to mesenchymal transition via sE-Cad.
  • RUNX3 functions as a tumor suppressor in gastric cancer by inhibiting YAP-TEAD complex.
  • These findings illustrate Hippo pathway crosstalk with RUNX factors in cancer.

Conclusions:

  • RUNX-TAZ/YAP interactions exhibit context-dependent roles in human cancer.
  • RUNX2 and RUNX3 present opposing functions in cancer progression.
  • Further elucidation of these complex interactions may reveal new therapeutic targets for cancer treatment.
Keywords:
Breast cancerGastric cancerHippo pathwayRUNX proteinsTAZTEADYAPsE-Cad

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