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Updated: Mar 5, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
Published on: May 11, 2013
Tripodal squaramide conjugates as highly effective transmembrane anion transporters
Xiong-Jie Cai1, Zhi Li1, Wen-Hua Chen1
1Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Abstract:
Two tripodal squaramide conjugates having 4-(trifluoromethyl)phenyl and 3,5-bis(trifluoromethyl)phenyl substituents were synthesized and found to exhibit highly efficient transmembrane anion transport with the EC50 values being 0.14 and 0.75mol%, respectively. Though one of them has been reported to act as a strong anion receptor, in particular for sulfate anions, these two compounds exhibit no significant selectivity with respect to the tested monovalent anions and a very low level of activity in the presence of sulfate anions.
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