Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

406
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
406
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

451
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
451
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

235
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
235
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

306
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
306
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

264
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
264
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

429
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
429

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linac-Based Radiosurgery Treatment for a Pineal Parenchymal Tumor.

Cureus·2025
Same author

Quality Improvement and Process Redesign for the Clinical Integration of Automated Breast Radiation Therapy Planning.

Practical radiation oncology·2025
Same author

Correction: "Generation and comparison of 3D dosimetric reference datasets for COMS eye plaque brachytherapy using model-based dose calculations" https://doi.org/10.1002/mp.16721.

Medical physics·2024
Same author

Prostate size, source configuration, and dosimetry dynamics of stranded <sup>125</sup>I seed implants.

Brachytherapy·2024
Same author

Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation.

Journal of applied clinical medical physics·2024
Same author

The impact of advancing the standard of care in radiotherapy on operational treatment resources.

Journal of applied clinical medical physics·2024

Related Experiment Video

Updated: Mar 5, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.8K

A brief look at model-based dose calculation principles, practicalities, and promise.

Ron S Sloboda1, Hali Morrison1, Brie Cawston-Grant1

  • 1Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton; Department of Medical Physics, Cross Cancer Institute, Alberta Health Services, Edmonton, Alberta, Canada.

Journal of Contemporary Brachytherapy
|March 28, 2017
PubMed
Summary

Model-based dose calculation algorithms (MBDCAs) offer improved accuracy for brachytherapy planning compared to TG-43. These advanced methods require detailed patient and applicator modeling for precise dose deposition calculations.

Keywords:
MBDCAMonte CarloTG-43dose calculation

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.6K

Related Experiment Videos

Last Updated: Mar 5, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.8K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.6K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Computational Dosimetry

Background:

  • Traditional TG-43 formalism for brachytherapy dose calculation, while practical, has limitations in accuracy.
  • Model-based dose calculation algorithms (MBDCAs) are emerging as a more accurate alternative.
  • MBDCAs utilize medical imaging data to solve the linear Boltzmann radiation transport equation for precise dose deposition.

Purpose of the Study:

  • To provide an overview of commercially available MBDCAs for brachytherapy.
  • To identify guidance for the safe and appropriate clinical implementation of MBDCAs.
  • To discuss considerations and early applications of MBDCAs in clinical practice.

Main Methods:

  • Review of three commercially available model-based dose calculation algorithms.
  • Analysis of guidance from professional societies and peer-reviewed literature.
  • Discussion of essential input data: patient geometry, material composition, and radiation source models.

Main Results:

  • MBDCAs provide enhanced dose calculation accuracy by incorporating detailed patient and applicator information.
  • Accuracy of MBDCAs is dependent on the quality of input data and the radiation source model.
  • Early applications demonstrate the potential of MBDCAs to improve brachytherapy, especially for low-energy sources.

Conclusions:

  • Model-based dose calculation algorithms represent a significant advancement in brachytherapy treatment planning.
  • Successful clinical implementation requires careful consideration of familiarization, commissioning, and quality assurance.
  • MBDCAs offer a pathway to improve brachytherapy practice, particularly for specific source types and clinical scenarios.