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Environmentally Responsive Systems for Drug Delivery.

Marcos L Bruschi1, Fernanda B Borghi-Pangoni1, Mariana V Junqueira1

  • 1Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa, Maringa. Brazil.

Recent Patents on Drug Delivery & Formulation
|March 31, 2017
PubMed
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Environmentally responsive drug delivery systems offer targeted delivery and reduced side effects. This review analyzes patents from 1975-2016, highlighting their therapeutic potential.

Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Engineering
  • Drug Delivery Systems

Background:

  • Environmentally responsive systems are advanced drug delivery formulations with significant application potential.
  • These smart systems respond to stimuli like temperature, pH, and light to release drugs at target sites.
  • They offer advantages such as reduced dosing frequency, fewer side effects, and lower costs compared to conventional methods.

Purpose of the Study:

  • To review and categorize patents related to environmentally responsive drug delivery systems.
  • To discuss the applications, dosage forms, and therapeutic importance of these systems.
  • To analyze the perspectives and future potential of this technology from 1975 to 2016.

Main Methods:

  • Systematic review and categorization of patent literature.
Keywords:
Drug deliverybiodegradable polymersresponsive systemsself-regulatingsensitive systemstechnology

Related Experiment Videos

  • Analysis of pharmaceutical devices and formulations utilizing responsive systems.
  • Discussion of various stimuli-responsive mechanisms including thermoresponsive, pH-responsive, and others.

    • Main Results:

    • Over twenty-five patents focus on thermoresponsive systems.
    • Fewer patents exist for glucose, ultrasound, and light-responsive systems.
    • Eight patents are pH-responsive, and four are electric-field responsive, with many patents covering multiple stimuli.

    Conclusions:

    • Environmentally responsive systems represent a valuable therapeutic modality.
    • Patent activity indicates significant interest and development in this field.
    • Further research and development hold promise for improved drug delivery and patient outcomes.