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Sustainable Difluoroalkylation Cyclization Cascades of 1,8-Enynes
1Department of Chemistry, Fuzhou University , Fuzhou 350116, China.
The Journal of Organic Chemistry
|April 8, 2017
Abstract:
We reported a visible-light-induced difluoroalkylation and cyclization cascade reaction of 1,8-enynes with broad substrate scopes in up to 92% isolated yields. This method provides a sustainable and efficient access to the synthesis of difluoroalkylated tetracyclic compounds under mild conditions.