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Research Frontiers in Traumatic Brain Injury: Defining the Injury
Andrew J Gardner1, Shirley L Shih2, Elizabeth V Adamov2
1Sports Concussion Program, Hunter New England Local Health District, Centre for Stroke and Brain Injury, School of Medicine and Public Health, University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia.
Abstract:
With the continued advancement in technology, such as increasingly sophisticated neuroimaging parameters, and the ongoing development of various scientific fields, like serum and blood biomarkers, genetics, and physiology, traumatic brain injury (TBI) research is a dynamic field of study. TBI remains a significant public health concern and research has continued to grow exponentially over the past decade. This review provides an overview of the frontiers of TBI research, from sports concussion to severe TBI, from acute and subacute injury to long-term/chronic outcomes, from assessment and management to prognosis, specifically examining recent neuroimaging, biomarkers, genetics, and physiologic studies.