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Microstructural MR Imaging Techniques in Multiple Sclerosis.

Massimo Filippi1, Paolo Preziosa1, Maria A Rocca1

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, Milan 20132, Italy.

Neuroimaging Clinics of North America
|April 11, 2017
PubMed
Summary
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Quantitative magnetic resonance imaging (MRI) techniques offer greater insight into multiple sclerosis (MS) pathophysiology and central nervous system damage compared to conventional MRI. These advanced methods improve the understanding of MS progression and disease substrates.

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Magnetic resonance imaging (MRI) is crucial for diagnosing and monitoring multiple sclerosis (MS).
  • Conventional MRI measures show a weak to moderate correlation with patients' clinical status in MS.
  • Advanced MRI techniques offer higher specificity for MS pathology.

Purpose of the Study:

  • To discuss insights from quantitative MRI techniques in defining MS pathophysiology.
  • To quantify progressive structural damage in the central nervous system (CNS) in MS.

Main Methods:

  • Application of quantitative MRI-based techniques.
  • Magnetization transfer imaging.
  • Diffusion tensor imaging.

Main Results:

Keywords:
Diffusion tensorGray matterMR imagingMagnetization transferMultiple sclerosisOptic nerveSpinal cordWhite matter

Related Experiment Videos

  • Quantitative MRI techniques demonstrate higher specificity for heterogeneous MS pathologic substrates.
  • These methods provide a better understanding of MS pathophysiology.
  • They allow quantification of progressive CNS structural damage.

Conclusions:

  • Quantitative MRI techniques are valuable for understanding MS.
  • These advanced methods improve the assessment of structural damage in MS.
  • Further application of these techniques can enhance MS patient management.