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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Brain Imaging01:14

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Related Experiment Video

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

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Neuroimaging and the Epilepsy Journey.

Benjamin H Brinkmann1

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA; Departments of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Neuroimaging Clinics of North America
|April 3, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Neuroimaging advances epilepsy care for drug-resistant patients. Advanced diagnostics like MRI and EEG precisely locate the seizure focus, guiding surgical interventions for better outcomes.

Keywords:
Drug resistanceEpilepsyFunctional imagingImage coregistrationStereotactic EEG

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Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
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Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
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Area of Science:

  • Neurology
  • Neurosurgery
  • Medical Imaging

Background:

  • Epilepsy affects millions globally, with a significant portion experiencing drug-resistant seizures.
  • Current epilepsy care pathways increasingly rely on advanced diagnostics to optimize treatment strategies.
  • Identifying the epileptogenic zone is crucial for effective surgical intervention in refractory epilepsy.

Purpose of the Study:

  • To review the role of neuroimaging in guiding treatment decisions for drug-resistant epilepsy.
  • To detail various noninvasive and invasive diagnostic modalities used in presurgical evaluation.
  • To illustrate the integration of these techniques for precise localization and surgical targeting.

Main Methods:

  • Review of noninvasive neuroimaging: structural CT and MR imaging, PET, ictal/interictal SPECT, and magnetoencephalography.
  • Description of invasive diagnostic approaches: video-scalp EEG monitoring and invasive EEG monitoring.
  • Integration of multimodal data for epileptogenic zone localization.
  • Case study demonstrating presurgical evaluation and stereoelectroencephalography-guided resection.

    • Main Results:

    • Neuroimaging modalities effectively support treatment decisions in drug-resistant epilepsy.
    • Multimodal diagnostic approaches enable accurate localization of the epileptogenic zone.
    • These techniques guide targeted surgical interventions such as resection, laser ablation, and neuromodulation.
    • Stereoelectroencephalography-guided resection proved effective in the illustrative case study.

    Conclusions:

    • Neuroimaging is integral to modern epilepsy care, particularly for drug-resistant cases.
    • A multimodal diagnostic strategy is essential for precise epileptogenic zone localization.
    • Advanced imaging and invasive monitoring facilitate successful surgical outcomes in epilepsy management.