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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Seizures: Classification01:13

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Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
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Focal Seizures
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Related Experiment Video

Updated: Apr 5, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Nuclear Imaging of Epilepsy.

Brian J Burkett1, Benjamin H Brinkmann2, Derek R Johnson1

  • 1Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA; Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Neuroimaging Clinics of North America
|April 3, 2026
PubMed
Summary

Brain imaging with single-photon emission computed tomography and positron emission tomography (PET) helps pinpoint epilepsy sources. These nuclear medicine scans guide treatment and surgery by showing brain function changes during seizures.

Keywords:
BrainEpilepsyFocal cortical dysplasiaNuclear medicinePETPET/MRSPECTSeizures

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Area of Science:

  • Nuclear medicine
  • Neurology
  • Medical imaging

Background:

  • Epilepsy management requires precise localization of seizure origins.
  • Nuclear medicine techniques like SPECT and PET assess brain function relevant to epilepsy.

Purpose of the Study:

  • To review the role of SPECT and PET in epilepsy management.
  • To highlight how these imaging modalities localize epileptogenic zones and assess functional changes.

Main Methods:

  • Utilizes brain single-photon emission computed tomography (SPECT) and positron emission tomography (PET).
  • Analyzes seizure-related changes in cerebral blood flow and glucose utilization.
  • Employs advanced quantitative and computational techniques for interpretation.

Main Results:

  • SPECT and PET can localize epileptogenic regions.
  • These studies assess broad functional brain changes in epilepsy patients.
  • Quantitative methods enhance study yield and interpretation.

Conclusions:

  • SPECT and PET are valuable noninvasive tools for guiding epilepsy treatment and surgery.
  • Future PET radiopharmaceuticals may offer enhanced diagnostic capabilities for epilepsy.