Related Experiment Videos
GRP78 levels, regional fat distribution and endometrial cáncer
Răzvan Ciortea1, Andrei M Malutan1, Lenuta M Angheluta1
1Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Background:
The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance.
Aim:
To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer.
Material And Methods:
Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured.
Results:
GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01).
Conclusions:
GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.