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Related Experiment Videos

[Intentional suicide with cyclizine].

Nikolaj Preus Hatting1, Peter Martin Hansen

  • 1nikolaj.preus.hatting@rsyd.dk.

Ugeskrift for Laeger
|April 19, 2017
PubMed
Summary
This summary is machine-generated.

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This case report details an intentional suicide using a high dose of cyclizine, an antihistamine. Over 70 mg/kg of cyclizine was ingested, leading to severe anticholinergic side effects.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Case Reports

Background:

  • Cyclizine is an antihistamine with known sedative, anticholinergic, and antiemetic properties.
  • Availability varies; it's over-the-counter in Denmark but prescription-only elsewhere.
  • The precise mechanism of action for cyclizine remains unelucidated.

Observation:

  • A case report involving intentional self-harm with cyclizine.
  • The ingested dose significantly exceeded therapeutic levels, surpassing 70 mg/kg.
  • Potential for potent anticholinergic side effects is noted at doses above 5 mg/kg.

Findings:

  • The case involved a deliberate overdose of cyclizine.
  • The high dosage confirmed the potential for severe anticholinergic toxicity.

Related Experiment Videos

  • This report highlights a rare instance of cyclizine used in a suicide attempt.

    • Implications:

    • Clinicians should be aware of the potential for severe toxicity with high-dose cyclizine, especially in overdose scenarios.
    • Understanding cyclizine's toxicological profile is crucial for emergency treatment.
    • This case underscores the importance of drug accessibility regulations and monitoring for misuse.