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[Measles after MMR-vaccination]

R van Grootveld1, L M Klitsie, D C M van der Kaay

  • 1Leids Universitair Medisch Centrum, afd. Medische Microbiologie, Leiden.

Nederlands Tijdschrift Voor Geneeskunde
|April 20, 2017
PubMed
Abstract

Insights

Mild symptoms like rash after the measles, mumps, and rubella (MMR) vaccine are common and mimic wild measles. Reassurance, not extensive testing, is often best for parents concerned about post-vaccination reactions.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • The Dutch national vaccination program includes the measles, mumps, and rubella (MMR) vaccine for all children.
  • Live attenuated viruses in the MMR vaccine replicate minimally post-administration.
  • This replication can cause mild, transient symptoms like fever, rash, and conjunctivitis, typically 5-14 days after vaccination.

Observation:

  • A 14-month-old boy presented with a significant rash 13 days post-MMR vaccination.
  • Diagnostic tests confirmed measles, leading to parental vaccine hesitancy.
  • The timing of symptoms raised questions about vaccine reaction versus wild-type infection.

Findings:

  • Post-MMR vaccination symptoms can closely resemble wild-type measles infection.
  • The low incidence of wild-type measles suggests vaccination reaction is a likely cause.
  • Symptoms typically manifest within 14 days of receiving the MMR vaccine.

Implications:

  • Distinguishing vaccine-induced symptoms from wild-type infections is crucial for public health.
  • Extensive diagnostic procedures can cause parental distress and vaccine hesitancy.
  • Healthcare providers should prioritize parental reassurance regarding expected post-vaccination responses.

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