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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

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Cinacalcet Hydrochloride.

Gamal A E Mostafa¹, Abdullah A Al-Badr¹

¹College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 23, 2017

Summary

This summary is machine-generated.

Cinacalcet hydrochloride, a calcimimetic agent, modulates parathyroid hormone secretion by enhancing calcium-sensing receptor sensitivity. This profile details its chemical properties, preparation, analysis, and biological effects.

Keywords:

Calcimimetic agent Cinacalcet hydrochloride Description Metabolism Methods of analysis Nomenclature Pharmacokinetics stability Physical characteristics Spectral properties Synthesis Uses

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Area of Science:

Pharmacology
Medicinal Chemistry
Analytical Chemistry

Background:

Cinacalcet hydrochloride is a calcimimetic agent targeting calcium-sensing receptors in the parathyroid gland.
It regulates parathyroid hormone secretion, crucial for calcium homeostasis.

Purpose of the Study:

To provide a comprehensive profile of cinacalcet hydrochloride.
To detail its chemical, physical, spectral, analytical, and biological characteristics.

Main Methods:

Characterization using techniques like X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and various spectroscopic methods (UV, NMR, MS).
Analysis via spectrophotometry, electrophoresis, fluorimetry, and HPLC (with/without MS).
Evaluation of stability, pharmacokinetics, and pharmacodynamics.

Main Results:

Detailed description of cinacalcet hydrochloride's nomenclature, structure, and physical properties.
Comprehensive spectral data including UV, vibrational, NMR, and mass spectra.
Reported stability, metabolism, pharmacokinetics, and pharmacodynamics.

Conclusions:

This profile offers a thorough understanding of cinacalcet hydrochloride's multifaceted properties.
It serves as a valuable resource for researchers and professionals working with this calcimimetic agent.