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Lomefloxacin
1College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Summary
Lomefloxacin, a broad-spectrum quinolone antibiotic, is detailed for its chemical properties and analytical methods. This profile aids in understanding its application for various infections like bronchitis and UTIs.
Area of Science:
- Pharmaceutical Chemistry
- Analytical Chemistry
- Microbiology
Background:
- Lomefloxacin is a second-generation difluorinated quinolone antibiotic.
- It exhibits broad-spectrum activity against various bacterial pathogens.
- Lomefloxacin is clinically used to treat infections such as bronchitis, urinary tract infections, and otitis media.
Purpose of the Study:
- To provide a comprehensive profile of the antibiotic lomefloxacin.
- To detail its chemical and physical characteristics.
- To review its analytical and synthetic methodologies.
Main Methods:
- Characterization using spectral methods: UV-Vis, vibrational spectroscopy, NMR (1D and 2D), and mass spectrometry.
- Review of analytical techniques including chromatography (HPLC, GC), capillary electrophoresis, and immunoassays.
- Description of pharmacokinetic properties and chemical synthesis routes.
Main Results:
- Detailed nomenclature, formulae, elemental composition, and physical properties were established.
- Various spectroscopic techniques confirmed the identity and purity of lomefloxacin.
- A wide array of analytical methods were identified for its quantification and quality control.
Conclusions:
- Lomefloxacin possesses well-defined chemical and physical characteristics.
- Multiple advanced analytical techniques are available for its identification and analysis.
- The comprehensive profile supports its therapeutic use and further research.