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Tolterodine Tartrate.
Gennady Ananchenko1, Jasmina Novakovic1
1Apotex Inc., Toronto, ON, Canada.
Summary
Tolterodine tartrate, a muscarinic antagonist for overactive bladders, has its physical, analytical, and synthesis profiles detailed. Stability studies cover the drug in solution and solid states.
Area of Science:
- Pharmacology
- Medicinal Chemistry
- Analytical Chemistry
Background:
- Tolterodine tartrate is a key muscarinic receptor antagonist.
- It is a primary treatment for overactive urinary bladder syndrome.
Purpose of the Study:
- To provide a comprehensive overview of tolterodine tartrate.
- To detail its physical, analytical, and ADME profiles.
- To discuss chemical synthesis and stability.
Main Methods:
- Literature review of peer-reviewed publications.
- Analysis of compendial reports (USP, EP).
- Inclusion of authors' proprietary data.
Main Results:
- Detailed physical and analytical characteristics of tolterodine tartrate.
- Overview of established chemical synthesis pathways.
- Stability data for tolterodine free base and l-tartrate salt.
Conclusions:
- Tolterodine tartrate exhibits well-defined properties relevant to its therapeutic use.
- Understanding its synthesis and stability is crucial for formulation and quality control.
- This review consolidates essential information for researchers and practitioners.
Keywords:
ADME profileAnalytical profileGauge-including projector augmented waveMethods of chemical synthesisMuscarinic receptor antagonistsSolid-state NMRStabilityStereoselective synthesisTolterodine and Tolterodine tartrateMore Related Videos
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