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Updated: Mar 3, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for
James A Clulow1, Elisabeth M Storck1, Thomas Lanyon-Hogg1
1Department of Chemistry, Imperial College London, London, UKSW7 2AZ. e.tate@imperial.ac.uk.
Abstract:
Sulforaphane is a small molecule isothiocyanate which exhibits anticancer potential, yet its biological targets remain poorly understood. Here we employ a competition-based chemical proteomics strategy to profile sulforaphane's targets and identify over 500 targets along with their relative affinities. These targets provide a new set of mediators for sulforaphane's bioactivity, and aid understanding of its complex mode of action.
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