Congenital Zika Virus Infection Induces Severe Spinal Cord Injury
Fernando S Ramalho1, Aparecida Y Yamamoto2, Luis L da Silva3
1Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, Ribeirão Preto, Brazil.
Summary
Congenital Zika virus (ZIKV) infection caused severe brain and spinal cord damage in two infants. The virus was detected in spinal cord neurons, confirming ZIKV
Area of Science:
- Neurology
- Virology
- Developmental Biology
Background:
- Congenital Zika virus (ZIKV) infection is a significant public health concern.
- Understanding ZIKV's impact on fetal development is crucial.
Observation:
- Two cases of fatal congenital ZIKV infection were analyzed.
- Detailed neuropathological examination of brain and spinal cord tissues was performed.
Findings:
- Severe brain anomalies including cerebral cortex and brainstem atrophy, and cerebellar aplasia were observed.
- Spinal cord exhibited architectural distortion, neuronal loss, and microcalcifications.
- ZIKV proteins, flavivirus-like particles, and ZIKV RNA were detected in spinal cord neurons.
Implications:
- This study highlights the devastating neurodevelopmental consequences of congenital ZIKV infection.
- Findings underscore the importance of ZIKV surveillance and prevention during pregnancy.
- Further research into ZIKV pathogenesis and therapeutic interventions is warranted.
