Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen
1Department of Chemistry University of Basel CH-4056 Basel;,
Chimia
|April 28, 2017
Abstract:
Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme.
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