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Quantitative magnetization transfer ultrashort echo time imaging using a time-efficient 3D multispoke Cones sequence.

Ya-Jun Ma¹, Eric Y Chang^1,2, Michael Carl³

¹Department of Radiology, University of California, San Diego, California, USA.

Magnetic Resonance in Medicine

|May 5, 2017

Summary

This summary is machine-generated.

This study introduces a fast 3D UTE-Cones-MT imaging technique for quantitative assessment of macromolecular and water content in tissues. The method enables rapid volumetric analysis of short T2 tissues, improving imaging efficiency.

Keywords:

cones magnetization transfer short T2 tissues two-pool modeling ultrashort echo time

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Area of Science:

Biomedical Imaging
Quantitative MRI
Magnetization Transfer Imaging

Background:

Quantitative ultrashort echo time (UTE) imaging is crucial for characterizing tissues with short T2 relaxation times.
Magnetization transfer (MT) imaging provides valuable information about macromolecular protons in tissues.
Accelerating quantitative UTE imaging with MT contrast is essential for clinical applications.

Purpose of the Study:

To accelerate quantitative ultrashort echo time (UTE) imaging.
To develop a time-efficient 3D multispoke Cones sequence with magnetization transfer (3D UTE-Cones-MT).
To enable accurate signal modeling for quantitative MT parameter estimation.

Main Methods:

Developed a 3D UTE-Cones-MT acquisition scheme with multispokes per MT preparation.
Employed a modified rectangular pulse (RP) approximation for two-pool MT modeling.
Validated the method using numerical simulations and cadaveric specimens (human Achilles tendon, bovine cortical bone) on a 3T scanner.

Main Results:

Numerical simulations confirmed accurate MT parameter estimation with the modified RP model and multispoke acquisition.
Experimental results for Achilles tendon showed a macromolecular fraction of 20.4 ± 2.0%.
Experimental results for cortical bone showed a macromolecular fraction of 59.4 ± 5.3%.

Conclusions:

The 3D multispoke UTE-Cones-MT sequence facilitates rapid volumetric assessment of macromolecular and water components.
This technique is suitable for tissues with short T2 relaxation times.
The developed method enhances the efficiency of quantitative MT imaging.