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Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

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Related Experiment Video

Updated: Mar 2, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

[Voxel-Based Morphometry for Schizophrenia: A Review].

Kiyotaka Nemoto¹

¹Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|May 9, 2017

Summary

This summary is machine-generated.

Voxel based morphometry (VBM) reveals significant brain volume differences in schizophrenia patients, including reductions in frontal and temporal regions and increases in striatal areas. These findings support ongoing debates about schizophrenia

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Last Updated: Mar 2, 2026

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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

Area of Science:

Neuroimaging
Psychiatry
Neuroscience

Background:

Voxel based morphometry (VBM) is widely used to investigate structural brain changes in schizophrenia.
Schizophrenia is associated with consistent patterns of regional brain volume alterations.

Purpose of the Study:

To summarize findings from VBM studies on brain volume in schizophrenia.
To discuss the implications of these findings for understanding schizophrenia's pathophysiology.

Main Methods:

Systematic review and meta-analysis of VBM studies in schizophrenia.
Analysis of regional brain volume differences between patients and healthy controls.

Main Results:

Patients with schizophrenia exhibit reduced gray matter volume in frontal, temporal (superior temporal gyrus, parahippocampal gyrus, amygdala), and limbic (insula, anterior cingulate cortex) regions.
Increased striatal volumes are observed in patients with schizophrenia.
Volume reductions are present even in first-episode schizophrenia and progress over time.

Conclusions:

VBM consistently identifies specific patterns of brain structural abnormalities in schizophrenia.
Findings support both neurodevelopmental and neurodegenerative hypotheses of schizophrenia.
Integrating VBM evidence into clinical practice remains a key challenge.