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Gossypol and Na+, K+ ATPase from human erythrocytes
1Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
Contraception
|November 1, 1988
Abstract:
The inhibition of Na+, K+ ATPase by gossypol has been proposed as a mechanism for the hypokalemia occurring in some patients receiving this drug. Gossypol acetic acid, 3 microM (higher concentration than present clinically), did not inhibit this enzyme prepared from erythrocytes from 5 humans. Thus, it is unlikely that gossypol inhibition of the usual form of this enzyme is the mechanism for the initiation of the hypokalemia.
Keywords:
AmericasAsiansBiologyClinical ResearchContraceptionContraceptive AgentsContraceptive Agents, MaleCultural BackgroundDemographic FactorsDeveloped CountriesDeveloping CountriesEconomic FactorsEnzyme InhibitorsEnzymesEnzymes And Enzyme InhibitorsEthnic GroupsFamily PlanningGossypolHuman VolunteersIn VitroNorth AmericaNorthern AmericaPhysiologyPopulationPopulation CharacteristicsResearch And DevelopmentResearch MethodologyTechnologyUnited States