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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Increased Six1 expression is associated with poor prognosis in patients with osteosarcoma
Lemeng Chao1,2, Jianfeng Liu3, Dewei Zhao3
1Graduate College, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.
Oncology Letters
|May 20, 2017
Summary
Increased expression of Sine oculis homeobox homolog 1 (Six1) protein in osteosarcoma is linked to advanced tumor stage and larger tumor size. Six1 serves as an independent prognostic factor, indicating poorer survival outcomes for patients.
Area of Science:
- Oncology
- Molecular Biology
- Developmental Biology
Background:
- Sine oculis homeobox homolog 1 (Six1) is a key developmental transcription factor.
- Six1 dysregulation is implicated in various cancers.
- Six1 is upregulated in osteosarcoma cell lines.
Purpose of the Study:
- To investigate the association between Six1 expression and clinicopathological characteristics in osteosarcoma.
- To determine if Six1 expression correlates with patient prognosis in osteosarcoma.
Main Methods:
- Immunohistochemistry was used to detect Six1 protein expression in 100 osteosarcoma patients.
- Kaplan-Meier survival analysis and Cox regression models were employed for prognostic assessment.
Main Results:
- Increased Six1 protein expression was observed in osteosarcoma.
- Six1 expression significantly correlated with Enneking stage and tumor size.
- Six1 was identified as an independent prognostic factor for osteosarcoma patients.
Conclusions:
- Positive Six1 protein expression is associated with tumor progression and poor survival in osteosarcoma.
- Six1 may serve as a valuable prognostic biomarker for osteosarcoma.
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