Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

4.2K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

24.4K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.4K
Regulation of Heart Rates01:31

Regulation of Heart Rates

4.3K
The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
4.3K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

4.5K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.5K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

7.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
7.7K
Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

2.4K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of MicroRNAs Carried by Extracellular Vesicles in Tumorigenesis Through Reprogramming the Mitochondrial Information Processing System.

International journal of molecular sciences·2026
Same author

Plumbagin-PLA- chitosan nanoformulation ameliorates inflammation in cervical cancer (SiHa) cells by enhancing bioavailability and targeted drug delivery.

Journal of biomaterials science. Polymer edition·2026
Same author

Formate reduces ischemic injury in the male heart by increasing protein <i>S</i> -nitrosation.

bioRxiv : the preprint server for biology·2026
Same author

Correction: A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy.

Oncotarget·2026
Same author

The association of extracellular vesicle (EV)-cargo miR-330-3p with postoperative delirium and a potential mechanism of tau phosphorylation and neuron toxicity.

bioRxiv : the preprint server for biology·2026
Same author

Mechanisms of microRNA trafficking to mitochondria in the heart.

Current opinion in physiology·2026
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K

MitomiRs Keep the Heart Beating.

Samarjit Das1, Hannah R Vasanthi2, Ramesh Parjapath2

  • 1Department of Pathology, Cardiovascular Division, Johns Hopkins University, Baltimore, MD, 21205, USA. sdas11@jhmi.edu.

Advances in Experimental Medicine and Biology
|May 29, 2017
PubMed
Summary
This summary is machine-generated.

Mitochondria contain unique microRNAs (miRNAs) that regulate gene expression within the cell's powerhouse. These specific molecules, termed "MitomiRs," influence mitochondrial function by targeting key genes.

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.6K
Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
11:37

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

7.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

8.0K
Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

8.6K
Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
11:37

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

7.1K

Area of Science:

  • Mitochondrial biology
  • Molecular genetics
  • Cellular regulation

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression.
  • Mitochondria, the powerhouses of the cell, have their own unique genetic and regulatory mechanisms.
  • The presence and function of miRNAs within mitochondria are an emerging area of research.

Purpose of the Study:

  • To identify and characterize microRNAs located within the mitochondrial compartment.
  • To investigate the role of these mitochondrial microRNAs in regulating mitochondrial and nuclear-encoded genes within mitochondria.
  • To define a specific class of miRNAs involved in mitochondrial function.

Main Methods:

  • Bioinformatic analysis to identify potential mitochondrial microRNAs.
  • Experimental validation of miRNA localization in mitochondria.
  • Functional assays to assess the impact of identified miRNAs on gene expression and mitochondrial function.

Main Results:

  • Identification of a distinct subset of microRNAs residing in mitochondria.
  • Demonstration that these microRNAs target both mitochondrial and nuclear-encoded genes within the mitochondria.
  • Evidence of altered mitochondrial function due to the action of these specific microRNAs.

Conclusions:

  • A novel class of microRNAs, termed "MitomiRs," has been identified within mitochondria.
  • MitomiRs play a significant role in regulating mitochondrial function through targeted gene regulation.
  • Further research into MitomiRs could reveal new therapeutic strategies for mitochondrial dysfunction.