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Updated: Mar 1, 2026

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
A portable visual detection method based on a target-responsive DNA hydrogel and color change of gold nanorods
Yu Mao1, Jiuxing Li, Jinmao Yan
1MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. ljzhou@xmu.edu.cn.
Abstract:
A new method based on a functional DNA crosslinked hydrogel as a target-responsive unit and gold nanorods (AuNRs) as a multicolor signal readout circuit was developed for the sensitive and visual detection of different targets. The color variation of the AuNR solution was correlated with the concentration of the target. This system can be extended to detect various targets by designing the corresponding target-responsive DNA hydrogels.

