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DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA?
U Wollina1, Naser M Abdel1, I Kruglikov1
1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt; Wellcomet GmbH, Karlsruhe, Germany.
Georgian Medical News
|June 3, 2017
Summary
Hair follicle cycling interacts with surrounding fat tissue. This cross-talk, including adipocyte changes, may drive hair loss and impact hair restoration treatments.
Area of Science:
- Dermatology
- Cell Biology
- Adipose Tissue Biology
Background:
- The interaction between hair follicles (HFs) and dermal adipose tissue is an emerging area of research.
- Understanding this cross-talk is crucial for both theoretical knowledge and practical applications in hair biology.
Purpose of the Study:
- To review and analyze existing data on the relationship between dermal adipose tissue and hair follicle cycling.
- To explore the potential role of adipocyte-myofibroblast transition in hair follicle miniaturization and androgenetic alopecia.
Main Methods:
- Literature review and analysis of experimental data, primarily from rodent models.
- Examination of cellular transitions and their impact on hair follicle dynamics.
Main Results:
- Rodent studies confirm a connection between hair follicle cycling and adjacent dermal adipose tissue.
- Adipocyte-myofibroblast transition is identified as a potential mechanism contributing to HF miniaturization.
- This transition may represent a key pathophysiological step in androgenetic alopecia.
Conclusions:
- The interplay between dermal fat and hair follicles is significant.
- Modulating the adipogenic environment of HFs could be a therapeutic strategy for alopecia.
- Improving the adipogenic environment may also benefit surgical hair restoration outcomes.
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