[STUDY OF HEPATOPROTECTIVE PROPERTIES OF RNA-CONTAINING DRUG "RN-13" ON THE MODEL OF ACUTE TETRAHLLORMETHANE INDUCED...

The aim of the study was to assess the hepatoprotective properties of the RNA-containing drug RN-13 on the model of acute CLL4 induced hepatitis in rats. To evaluate hepatoprotective properties of the RNA-containing drug RN-13 42 female rats were used. RN-13 increases the survival rate of animals with acute tetrachloromethane hepatitis. The hepatoprotective properties of RN-13 were confirmed by biochemical and morphological data. RN-13 helps to reduce the activity of alanine aminotransferase, which indicates its ability to limit cytolysis syndrome. Morphological studies confirm the ability of RN-13 to prevent destruction of liver tissue, preserve the radial structure of the hepatic lobes, and limit the development of hydropic and fatty degeneration.