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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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The person's health status fluctuates continually, varying from being in good health to becoming ill and returning to being healthy. To understand the concept of illness prevention, there are two models. First, the health-illness continuum model is a graphic representation of an individual's wellness. It states that a person is considered healthy in the absence of physical disease and the presence of good emotional health.
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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
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Related Experiment Video

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Looking Back: Disease Modeling

    Cell Stem Cell
    |June 3, 2017
    PubMed
    Summary

    Stem cell models for human diseases have advanced drug discovery and personalized medicine. A review of highly cited papers reveals their significant impact on research and therapeutic development.

    Area of Science:

    • Stem cell biology
    • Disease modeling
    • Drug discovery

    Background:

    • Stem cell-based models have emerged as powerful tools in understanding human disorders.
    • Their application has significantly contributed to advancements in drug discovery and the development of precision medicine.

    Purpose of the Study:

    • To assess the influence of seminal stem cell research papers.
    • To understand how these studies have shaped current research directions in the field.

    Main Methods:

    • A retrospective analysis of citations for selected popular stem cell papers.
    • Surveys and interviews with authors who cited these influential studies.

    Main Results:

    • The cited papers have demonstrably guided research in stem cell applications.

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  • Authors reported significant impact on their work, leading to new therapeutic strategies.

    • Conclusions:

    • Stem cell models are pivotal in advancing biomedical research and clinical applications.
    • Continued focus on stem cell research promises further breakthroughs in treating human diseases.