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Oxidative stress and angiogenesis in primary hyperparathyroidism
Mariusz Deska1, Ewa Romuk2, Oliwia Anna Segiet3
1School of Medicine with the Division of Dentistry, Department of General and Endocrine Surgery, Medical University of Silesia, Bytom, Poland.
European Surgery : ACA : Acta Chirurgica Austriaca
|June 10, 2017
Summary
Parathyroidectomy reduces oxidative stress and lipid peroxidation in primary hyperparathyroidism patients. However, this normalization of antioxidant status does not impact angiogenesis in parathyroid tissue.
Area of Science:
- Endocrinology
- Biochemistry
- Cardiovascular Medicine
Background:
- Elevated parathormone (PTH) in primary hyperparathyroidism (PHPT) affects angiogenesis and antioxidant enzyme activity.
- Parathyroidectomy (PTX) in PHPT patients lowers PTH, potentially improving antioxidant status and reducing mortality risk.
Purpose of the Study:
- To assess antioxidant enzyme activity and free radical products post-parathyroidectomy.
- To evaluate the correlation between oxidative stress and angiogenic parameters after PTX.
Main Methods:
- Measured total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), ceruloplasmin (CER), lipid hydroperoxides (LHP), and malondialdehyde (MDA) before and after PTX.
- Assessed immunohistological expression of VEGF, CD31, and CD106 in parathyroid tissue.
Main Results:
- PTX significantly increased TAC and CER, while decreasing TOS, MDA, SOD (cytoplasmic), OSI, and LHP.
- No significant correlation was found between changes in oxidative stress markers and angiogenic factors (VEGF, CD31, CD106) in parathyroid tissue.
Conclusions:
- Parathyroidectomy down-regulates lipid peroxidation and reduces oxidative stress in PHPT patients.
- The observed decrease in OSI post-PTX reflects reduced oxidative stress.
- Changes in antioxidant status after PTX do not appear to influence angiogenesis in parathyroid tissue.
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