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Updated: Feb 28, 2026

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
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[Intraoperative Optical Coherence Tomography in Vitreoretinal Surgery: Clinical Experiences and Future Developments]
Mathias M Maier1, Ali Nasseri1, Carsten Framme2
1Augenklinik, Klinikum rechts der Isar, Technische Universität München.
Summary
Integrated optical coherence tomography (iOCT) provides real-time visualization during ophthalmic surgery. This technology aids surgeons in adapting procedures by precisely depicting microstructural changes, enhancing surgical outcomes for posterior segment pathologies.
Area of Science:
- Ophthalmology
- Medical Imaging
- Surgical Technology
Background:
- High-resolution optical coherence tomography (OCT) offers superior visualization of ophthalmic microstructures compared to conventional imaging.
- Integrated OCT (iOCT) into ophthalmic microscopes allows for high-resolution, real-time visualization during procedures.
Purpose of the Study:
- To report on the initial clinical application of microscope-integrated OCT (iOCT) in posterior segment surgeries.
- To evaluate the utility of iOCT in real-time surgical guidance and decision-making.
Main Methods:
- A cohort of 110 patients undergoing posterior segment surgery utilized a microscope with integrated OCT (iOCT).
- iOCT was employed to visualize microstructural changes and retinal anatomy during surgical interventions.
Main Results:
- iOCT precisely depicted microstructural changes occurring during surgery.
- Real-time visualization of retinal morphology enabled surgeons to adapt surgical flow and tailor procedures.
- iOCT data facilitated patient- and operation-specific interventional strategies.
Conclusions:
- Current iOCT systems lack measurement, tracking, and autofocus capabilities, and are hindered by metal instruments.
- Future advancements including OCT-friendly surgical tools, tracking, autofocus, and higher resolution are needed for comprehensive intraoperative diagnostics.
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