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[Association of GH and IGF-1 Burden with Cardiac Structural and Functional Changes in Acromegaly Patients]

Shuo Zhang1, Yi-Lin Li1, Xiao-Peng Guo1

  • 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|June 16, 2017
PubMed

Insights

Elevated growth hormone (GH) and insulin-like growth factor (IGF-1) burden are linked to cardiac abnormalities in acromegaly patients. These hormonal burdens correlate with specific echocardiographic changes, indicating potential cardiac complications.

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Background:

  • Acromegaly is characterized by excessive growth hormone (GH) and insulin-like growth factor 1 (IGF-1) secretion.
  • These hormonal excesses can lead to significant cardiovascular complications.
  • Understanding the relationship between hormonal burden and cardiac changes is crucial for patient management.

Purpose of the Study:

  • To investigate the association between GH and IGF-1 burden and cardiac structural and functional alterations in acromegaly.
  • To identify specific echocardiographic parameters affected by hormonal burden in acromegaly patients.

Main Methods:

  • A retrospective analysis of 99 acromegaly patients.
  • Patients were categorized into normal and abnormal echocardiography groups based on standard parameters.
  • Correlation analyses were performed between disease duration, mean GH/IGF-1 levels, GH/IGF-1 burden, and echocardiographic data.

Main Results:

  • Nearly half of the patients (48.5%) exhibited abnormal echocardiography findings, including chamber enlargement and functional abnormalities.
  • Patients with abnormal echocardiograms generally had higher GH and IGF-1 burdens.
  • Significant correlations were found between GH burden and left ventricular dimensions (LVESD), and IGF-1 burden with left ventricular function (LVEF), atrial/ventricular dimensions, wall thickness, and diastolic function (E/A ratio).

Conclusions:

  • GH and IGF-1 burden are associated with echocardiographic abnormalities in acromegaly.
  • These hormonal burdens are linked to specific cardiac structural and functional changes, highlighting their role in acromegaly-related cardiomyopathy.
Abstract

Keywords:
AcromegalyEchocardiographyGrowth hormoneHeartInsulin-like growth factor 1

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