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Related Experiment Video

Updated: Feb 28, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

Combinatorial immunotherapy and nanoparticle mediated hyperthermia.

Austin J Moy¹, James W Tunnell¹

¹Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.

Advanced Drug Delivery Reviews

|June 20, 2017

Summary

This summary is machine-generated.

Combining immune checkpoint therapy with nanoparticle-assisted hyperthermia shows promise for expanding cancer treatment options. This combinatorial approach aims to improve long-term disease remission for more patients and tumor types.

Keywords:

Cancer Combinatorial treatment Hyperthermia Immunotherapy Laser Magnetic Nanoparticles Near infrared Radiofrequency

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Published on: May 22, 2020

Area of Science:

Oncology
Immunotherapy
Nanomedicine

Background:

Immune checkpoint therapy is a key immunotherapy for advanced melanoma and other cancers.
Current limitations restrict its effectiveness to a subset of patients and tumor types.
Combinatorial treatments are crucial for broadening therapeutic applications.

Purpose of the Study:

To review the combination of immune checkpoint therapy and nanoparticle-assisted localized hyperthermia.
To explore the potential of this novel combinatorial approach for cancer treatment.

Main Methods:

Overview of nanoparticle hyperthermia approaches.
Review of the current state of immune checkpoint therapy.
Analysis of recent reports on combined therapies.

Main Results:

Discussion of nanoparticle hyperthermia techniques.
Summary of immune checkpoint therapy efficacy and limitations.
Exploration of synergistic effects in preclinical and clinical studies.

Conclusions:

The combination of immune checkpoint therapy and nanoparticle-assisted hyperthermia presents a promising strategy.
Further research is needed to optimize this approach for broader clinical application.
This review highlights future research directions for enhanced cancer treatment.