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Phenolic Compounds in Antimicrobial Therapy.

Santi M Mandal1, Renata O Dias2, Octavio L Franco2,3

  • 11 Central Research Facility, Indian Institute of Technology , Kharagpur, India .

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|June 30, 2017
PubMed
Summary
This summary is machine-generated.

Phenolic compounds like tannic acid and epigallocatechin gallate show promise as antioxidants. They possess antibacterial, biofilm, and beta-lactamase inhibition properties, potentially reducing antibiotic side effects.

Keywords:
antimicrobialsbacterial infectionmolecular modelingphenolic compoundsresistance

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Area of Science:

  • Antimicrobial research
  • Natural product chemistry
  • Pharmacology

Background:

  • Antibiotic therapy can lead to adverse effects.
  • Antioxidant therapy, particularly with phenolic compounds (PCs), may mitigate these side effects.
  • Identifying effective PCs for supportive antibiotic therapy is crucial.

Purpose of the Study:

  • To screen phenolic compounds (PCs) for antibacterial, biofilm, and beta-lactamase inhibition activity.
  • To identify optimal PCs for use as supportive supplements during antibiotic treatment.
  • To evaluate the potential of PCs in combating antibiotic-resistant bacteria.

Main Methods:

  • Screening of various phenolic compounds (PCs) for antimicrobial efficacy against Staphylococcus epidermidis and Pseudomonas aeruginosa.
  • Assessing the beta-lactamase inhibition activity of selected PCs.
  • Utilizing both in vitro and in silico analyses to determine beta-lactamase inhibition potential.
  • Evaluating biofilm inhibition capabilities of the most promising PCs.

Main Results:

  • Tannic acid, epigallocatechin gallate, rutin, and eugenol demonstrated significant antibacterial activity.
  • Epigallocatechin gallate, tannic acid, quercetin, and epicatechin effectively inhibited beta-lactamase activity.
  • Tannic acid and epigallocatechin gallate exhibited the strongest beta-lactamase inhibition in both in vitro and in silico models.
  • Tannic acid and epigallocatechin gallate showed combined antibacterial, beta-lactamase, and biofilm inhibition properties.

Conclusions:

  • Tannic acid and epigallocatechin gallate are highly effective phenolic compounds for supportive antibiotic therapy.
  • These PCs possess multifaceted activity, including antibacterial, biofilm, and beta-lactamase inhibition.
  • Further research into these compounds could lead to novel strategies for enhancing antibiotic efficacy and reducing side effects.