Related Experiment Video
Updated: Aug 10, 2026
03:59
Surgical Correction for Pediatric Epiblepharon and Trichiasis
Published on: July 8, 2025
672
LASH: A Review of the Current Literature
William Kingston1, Rashmi Halker2
1Mayo Clinic Arizona, Phoenix, AZ, USA. willkingston@gmail.com.
Current Pain and Headache Reports
|July 7, 2017
Summary
Long-lasting autonomic symptoms with associated hemicranias (LASH) is a rare disorder. Current findings suggest LASH may be an extreme variant of trigeminal autonomic cephalalgias (TACs).
Area of Science:
- Neurology
- Headache Medicine
- Autonomic Disorders
Background:
- Long-lasting autonomic symptoms with associated hemicranias (LASH) is a rare neurological disorder.
- Understanding LASH is limited due to its rarity.
Purpose of the Study:
- To review and synthesize current knowledge on LASH.
- To evaluate LASH in the context of other headache disorders.
Main Methods:
- Literature review of documented LASH cases.
- Comparative analysis with trigeminal autonomic cephalalgias (TACs).
Main Results:
- Only four cases of LASH are documented in medical literature.
- LASH shares characteristics and indomethacin response with TACs.
- LASH may represent an extreme presentation of TACs, similar to paroxysmal hemicrania (PH) and hemicrania continua (HC).
Conclusions:
- The pathophysiology and epidemiology of LASH require further investigation.
- LASH's position within the spectrum of TACs warrants additional research.
Related Concept Videos
01:38What are Lipids?
Overview
00:46Feedback Inhibition
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
01:34Crossing Over
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
01:32The Retina
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
01:01Feedback Loops
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.