Related Experiment Video
Updated: Feb 26, 2026
09:48
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
8.7K
Coexisting Brenner Tumor and Endometrial Carcinoma
Mitakshara Sharma1, Babita Khangar1, Varuna Mallya1
1Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Journal of Mid-Life Health
|July 15, 2017
Summary
Brenner tumors, rare ovarian neoplasms, can elevate estrogen levels, potentially leading to endometrial pathologies like carcinoma. This case highlights a coexisting Brenner tumor and endometrial cancer in a postmenopausal woman.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
Background:
- Brenner tumors are rare ovarian neoplasms, classified as benign, borderline, or malignant.
- These tumors can be associated with estrogen production, disrupting the estrogen-progesterone balance.
Observation:
- A rare case of coexisting Brenner tumor and well-differentiated endometrial carcinoma is presented.
- The patient was a 55-year-old nulliparous postmenopausal woman.
Findings:
- Elevated estrogen from the Brenner tumor likely stimulated endometrial proliferation.
- This hormonal imbalance contributed to the development of endometrial pathology, including carcinoma.
Implications:
- Highlights the importance of considering hormonal effects of ovarian neoplasms.
- Underscores the need for vigilance in diagnosing endometrial pathologies in patients with Brenner tumors.
Related Concept Videos
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
01:16Uterine Tubes
2.9K
The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
2.9K
01:18Uterus and Cervix
6.1K
The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs...
6.1K
01:24Disorders of the Female Reproductive System
4.6K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.6K