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The Objective Assessment of Cough Frequency in Bronchiectasis
Arietta Spinou1, Kai K Lee2, Aish Sinha1
1Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, SE5 9RS, UK.
Lung
|July 15, 2017
Summary
Patients with bronchiectasis experience frequent coughing, impacting their health. Objective cough monitoring revealed sputum, exacerbations, and age as key predictors, not lung function.
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Research
Background:
- Cough is a primary symptom in bronchiectasis, significantly affecting patients' quality of life.
- Objective quantification of cough frequency is crucial for understanding its impact and developing effective treatments.
Purpose of the Study:
- To objectively measure cough frequency in bronchiectasis patients using a cough monitor.
- To explore the relationship between objective cough frequency and health status.
- To identify clinical predictors of cough frequency in bronchiectasis.
Main Methods:
- Compared 54 bronchiectasis patients with 35 healthy controls.
- Measured 24-hour objective cough counts, health status (Leicester Cough Questionnaire, Bronchiectasis Health Questionnaire), and lung function.
- Utilized multivariate analysis to determine predictors of cough frequency.
Main Results:
- Bronchiectasis patients had significantly higher objective cough frequency (184.5 vs. 20.6 coughs/24h) and impaired health status.
- Objective cough frequency strongly correlated with subjective health status measures (LCQ: r=-0.52, BHQ: r=-0.62).
- Sputum production, exacerbations, and age were independent predictors of cough frequency, explaining 52% of variance. Lung function was not associated with cough frequency.
Conclusions:
- Cough is a significant symptom in bronchiectasis, influenced by sputum, exacerbations, and age.
- Objective cough monitoring offers valuable insights into bronchiectasis and may serve as an important outcome measure.
- Further research into ambulatory cough monitoring is warranted for clinical application in bronchiectasis management.
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