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Systemic therapies in atopic dermatitis: The pipeline
Yael Renert-Yuval1, Emma Guttman-Yassky2
1Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Clinics in Dermatology
|July 16, 2017
Summary
New targeted therapies offer improved efficacy and tolerability for moderate to severe atopic dermatitis (AD). Clinical trials of these novel treatments are also advancing our understanding of AD pathogenesis and its complex molecular characteristics.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Atopic dermatitis (AD) is a prevalent inflammatory skin condition marked by T-cell activation.
- AD exhibits T helper type 2 (Th2)/Th22 polarization, with specific subtypes showing increased Th17/interleukin 23 skewing.
- Current systemic treatments for moderate to severe AD have limitations in efficacy, safety, and patient compliance.
Purpose of the Study:
- To review developing therapeutics for atopic dermatitis based on pathway-specific mechanisms.
- To outline the complex molecular characteristics of AD.
- To highlight the unmet need for improved treatments for moderate to severe AD.
Main Methods:
- Review of current literature on targeted therapies for atopic dermatitis.
- Analysis of pathway-specific mechanisms of novel AD therapeutics.
- Examination of clinical trial data for emerging AD treatments.
Main Results:
- Multiple targeted drugs are under investigation for moderate to severe AD, showing promise for increased tolerability, specificity, and efficacy.
- Clinical testing of these targeted drugs provides insights into AD pathogenesis.
- The review categorizes developing AD therapeutics by their mechanism of action.
Conclusions:
- Targeted therapies represent a significant advancement in treating moderate to severe atopic dermatitis.
- Further research into targeted treatments will deepen the understanding of AD's complex molecular underpinnings.
- There is a substantial unmet need for more effective and safer AD treatments.
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