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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

278
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
278
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

283
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Related Experiment Video

Updated: Feb 25, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
08:32

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

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Dysphagia in the Elderly.

Scott M Smukalla1, Irina Dimitrova2, Jeremy M Feintuch3

  • 1Department of Gastroenterology, Center for Esophageal Disease, NYU School of Medicine, 240 East 38th St., 23rd Floor, New York, NY, 10016, USA.

Current Treatment Options in Gastroenterology
|July 31, 2017
PubMed
Summary
This summary is machine-generated.

Dysphagia, or difficulty swallowing, is common in older adults and impacts quality of life. New diagnostic tools and less invasive treatments offer personalized management for elderly patients with swallowing problems.

Keywords:
DilationDysphagiaEsophagealLower esophageal sphincterOropharyngealUpper esophageal sphincter

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Related Experiment Videos

Last Updated: Feb 25, 2026

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Area of Science:

  • Geriatrics
  • Gastroenterology
  • Otolaryngology

Background:

  • Dysphagia is a prevalent condition in the elderly, particularly in institutionalized individuals, leading to significant morbidity.
  • It can stem from oropharyngeal or esophageal issues, with oropharyngeal dysphagia being common and multifactorial in this demographic.
  • Limited historical treatments focused on supportive care and dietary modifications.

Purpose of the Study:

  • To review the evaluation and management of dysphagia in the elderly population.
  • To highlight how traditional and emerging therapies are enabling more personalized patient care.
  • To discuss advancements in understanding and treating both oropharyngeal and esophageal dysphagia.

Main Methods:

  • Review of current literature on dysphagia in the elderly.
  • Discussion of diagnostic advancements, including functional luminal imaging probe (FLIP) and esophageal manometry.
  • Analysis of evolving therapeutic strategies for oropharyngeal and esophageal dysphagia.

Main Results:

  • Novel technologies are improving the understanding of oropharyngeal dysphagia pathophysiology.
  • Emerging treatments like endoscopic balloon dilation for UES dysfunction show promise.
  • Less invasive solutions for esophageal pathologies are expanding treatment options for elderly patients.

Conclusions:

  • An individualized approach is crucial for managing dysphagia in the elderly, considering comorbidities and functional status.
  • Advancements in diagnostics and therapeutics are leading to more nuanced and personalized management strategies.
  • Further research is expected to enhance the efficacy and availability of novel treatments for elderly patients with dysphagia.