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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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ACUTE RENAL FAILURE - CHANGING TRENDS
1Classified Specialist Medicine & Nephrologist, Army Hospital, Delhi Cantt 110010.
Medical Journal, Armed Forces India
|August 4, 2017
Summary
This study on acute renal failure in Calcutta found infections and volume depletion as leading causes. Acute tubular necrosis was the most common renal lesion, with infection and multisystem issues worsening outcomes.
Area of Science:
- Nephrology
- Internal Medicine
- Epidemiology
Background:
- Acute renal failure (ARF) presents a significant clinical challenge.
- Understanding evolving etiological trends and prognostic indicators is crucial for patient management.
Purpose of the Study:
- To investigate the changing incidence and causes of ARF.
- To identify factors influencing prognosis in ARF patients.
Main Methods:
- A prospective study involving 120 patients with ARF.
- Data collection included patient demographics, etiological factors, renal histology, and outcomes.
Main Results:
- The mean age of patients was 33.7 years; 75% had medical risk factors.
- Leading causes included septicaemia (25.6%), drugs (16.7%), falciparum malaria (16.6%), and volume depletion (13.3%).
- Acute tubular necrosis was the most frequent histological finding (53.3%).
Conclusions:
- Septicemia and falciparum malaria are significant contributors to ARF in this region.
- Associated infection and multisystem involvement are poor prognostic indicators in fatal ARF cases.
Keywords:
Acute renal failure
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